Dynamic metabolic imaging of hyperpolarized [2-13 C]pyruvate using spiral chemical shift imaging with alternating spectral band excitation
نویسندگان
چکیده
منابع مشابه
Multiband excitation pulses for hyperpolarized 13C dynamic chemical-shift imaging.
Hyperpolarized 13C offers high signal-to-noise ratios for imaging metabolic activity in vivo, but care must be taken when designing pulse sequences because the magnetization cannot be recovered once it has decayed. It has a short lifetime, on the order of minutes, and gets used up by each RF excitation. In this paper, we present a new dynamic chemical-shift imaging method that uses specialized ...
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Introduction Rapid chemical shift imaging (CSI) techniques are of considerable interest for hyperpolarized C metabolic imaging [1,2]. Undersampled spiral CSI (spCSI) using a free induction decay (FID) acquisition mode has been applied to real-time metabolic imaging with acquisition times of less than 1 s per slice [3]. The FID acquisition necessitates phase correction during reconstruction for ...
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PURPOSE To develop and optimize a rapid dynamic hyperpolarized 129 Xe ventilation (DXeV) MRI protocol and investigate the feasibility of capturing pulmonary signal-time curves in human lungs. THEORY AND METHODS Spiral k-space trajectories were designed with the number of interleaves Nint = 1, 2, 4, and 8 corresponding to voxel sizes of 8 mm, 5 mm, 4 mm, and 2.5 mm, respectively, for field of...
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Within the last decade hyperpolarized [1-13C] pyruvate chemical-shift imaging has demonstrated impressive potential for metabolic MR imaging for a wide range of applications in oncology, cardiology, and neurology. In this work, a highly efficient pulse sequence is described for time-resolved, multislice chemical shift imaging of the injected substrate and obtained downstream metabolites. Using ...
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shot spCSI in 125 ms. Color scale is the same for all images (with Pyr scaled down by 2.5), threshold at 15% of maximum. (b) Same as (a), but acquired with FIDCSI (Tacq = 24 s). Fig. 2: Time courses of the average signal intensity from ROIs in the left kidney (solid) and heart (dashed) for Pyr (blue circle), Lac (red square), and Ala (green cross). The time courses for Pyr are scaled down by a ...
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ژورنال
عنوان ژورنال: Magnetic Resonance in Medicine
سال: 2013
ISSN: 0740-3194
DOI: 10.1002/mrm.24871